Negative pressure wound therapy (NPWT) offers clinicians an important option for the advanced management of many wound types. Over the past 15 years NPWT has revolutionised care for many patients with chronic and acute wounds and has prompted the development of new NPWT systems, including portable, single-use and wound-specific devices. This requires a clear understanding of the characteristics of the various NPWT systems and applications. The V.A.C.Ulta™ Therapy System (KCI) is a new device that combines V.A.C.® Therapy (KCI) with the added option of the controlled delivery of topical instillation solutions to the wound bed using V.A.C. VeraFlo™ Therapy (KCI).