Bone marrow promotes wound repair with stem cells and granulocytes
Researchers have found that bone marrow-derived cells (BMDC) promote wound healing using granulocytes and stem cells when stimulated by a colony-stimulating growth factor.
By activating bone marrow with the granulocyte colony-stimulating factor (G-CSF) the release of BMDCs help heal wounds at an accelerated rate preventing further skin damage.
Using a green fluorescent protein that attaches to granulocytes and stem cells, researchers were able to physically see a proliferation of cell activity after mobilising the G-CSF in mouse models. The cells were attributed to the release of BMDCs, which were not observed in the control mice. The BMDCs differentiated into epidermal stem cells or transit-amplifying cells, which helped to stimulate wound repair. Mice in the trial group healed in 12.5 days, and mice in the control group healed in 18 days on average.
'The potential trophic effects of G-CSF on bone marrow stem cells to accelerate wound healing could have a significant clinical impact,' the researchers concluded.
To read the study, click here.
Image: Skeleton from the book Nel Mondo Dei Fanciulli. Credit: perpetualplum on Flickr.