Using a flexibly crosslinked acellular biomatrix in clinical practice: case reports
Advances in the treatment of problematic wounds and tissue repair have led to the development of materials that may assist with optimizing the wound bed environment. The term biomodulation has been used to describe the process through which materials affect cell activity in a wound undergoing the repair process. Collagen-derived xenografts are of particular importance as they may have a therapeutic effect on wounds, especially those characterized by high levels of inflammation.
About this document
This document looks at the clinical application of a specific flexibly crosslinked acellular matrix, Unite® Biomatrix, in a wide range of wounds where healing has been delayed or complicated by comorbidities. Unite® Biomatrix is a new acellular matrix that has been categorized as a xenograft.
Unite® Biomatrix is derived from native equine pericardium - primarily consisting of type I collagen matrix from which all donor cells and endogenous intracellular debris have been removed, leaving only bioactive components and a pliable collagen matrix. The xenograft also undergoes a stabilising process during manufacture to flexibly crosslink the product, helping to prevent it from being broken down prematurely by proteases in the wound bed.
It is supplied as a sterile <1mm thick xenograft with a four-year shelf life and can be stored at room temperature. Unite® Biomatrix is available fenestrated or non-fenestrated: the fenestrated option is suitable for wounds that are moderately to highly exuding, while non-fenestrated Unite® Biomatrix may be placed in a surgical mesher to cover a wider area. It is designed to support the healing of a chronic wound with a single application.
Clinical case reports suggest that Unite® Biomatrix can be used for hard-to-heal wounds in patients with complicated comorbidities (Wounds International, 2011). Unite® Biomatrix is intended for the repair or replacement of soft tissue, including:
- Partial- and full-thickness wounds
- Draining wounds
- Pressure ulcers
- Venous ulcers
- Chronic vascular ulcers
- Diabetic ulcers
- Trauma wounds (e.g. abrasions, lacerations, partial thickness burns, skin tears)
- Surgical wounds (e.g. donor sites/grafts, post-laser surgery, post-Mohs' surgery, podiatric wounds, and dehisced surgical incisions).
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